top of page


“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

  • Zhang Q*, Kandasamy L, Tsukamoto M, Inoue K, Pires M, Shin MS, Tanaka M, Nagasawa Y, Sambuu T, Itohara S, Ogawa S, Young L(2022). Transcriptional lability of brain oxytocin receptor (Oxtr) generates diversity in brain OXTR distribution and social behaviors. Cold Spring Harbor Laboratory Preprint Biorxiv.

  • Larry Young, Qi Zhang. (2021) On the origins of social behavior diversity. The Japanese Journal of Animal Psychology. Invited Review. 

  • Kandasamy LC, Tsukamoto M, Banov V, Tsetsegee S, Nagasawa Y, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young LJ, Zhang Q. (2021) Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models. Human Molecular Genetics. 2021 Feb 19.

  • Masuda A, Sano C, Zhang Q, Goto H, McHugh T, Fujisawa S, Itohara S.(2020) The hippocampus encodes delay and value information during delay-discounting decision making. Elife 2020 Feb 20;9:e52466. doi: 10.7554/eLife.52466.

  • Masuda A, Sano C, Zhang Q, Goto H, McHugh T, Fujisawa S, Itohara S.(2018) The hippocampus encodes delay and value information during delay-discounting decision making. Biorxiv, 2018 December; doi:

  • Prosselkov P, Zhang Q, Goto H, Polygalov D, McHugh TJ, Itohara S. (2018). Behavior variability of a conditional gene knockout mouse as a measure of subtle phenotypic trait expression. The case of mouse brain executive function distortion. BioRxiv, doi: ttps://

  • Prosselkov P, Zhang Q, Goto H, Polygalov D, McHugh T, Itohara S. (2017) Molecular correlation of mouse executive function. Top-down and bottom-up complementations by presynaptic vertebrate brain-specific Ntng gene paralogs. Biorxiv, 2017 July; doi:

  • Zhang Q, Sano C, Masuda A, Ando Reiko, Tanaka M, Itohara S.(2016) Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits Scientific Reports June; doi: 10.1038/srep28750

  • Zhang Q, Goto H, Akiyoshi-Nishimura S, Prosselkov P, Sano C, Matsukawa H , Yaguchi K, Nakashiba T, and Itohara S.(2016) Diversification of behavior and postsynaptic properties by Netrin-G presynaptic adhesion family proteins. Molecular Brain Jan 8;9(1):6. doi: 10.1186/s13041-016-0187-5

  • Prosselkov P, Polygalov D, Zhang Q, McHugh T, Itohara S.(2016) Cognitive domains function complementation by NTNG gene paralogs. Biomed Genet Genomics Volume 1(1): 24-33; doi: 10.15761/BGG.1000105

  • Prosselkov P, Hashimoto R, Polygalov D, Ohi K, Zhang Q, McHugh T, Takeda M , Itohara S.(2016) Cognitive endophenotypes of modern and extinct hominins associated with Ntng gene paralogs. Biomed Genet Genomics Volume 1(1): 5-13; doi: 10.15761/BGG.1000103

  • Matsukawa H, Nishimura S, Zhang Q, Luján R, Goto H, Yaguchi K, Hashikawa T, Shigemoto , Itohara S.(2014)  Netrin-G/NGL complexes encode functional synaptic diversification. The Journal of Neuroscience, 34(47):15779-92

  • Ono K, Clvairoly A, Nomura T, Gotoh H, Uno A, Armant O, Zhang Q, Takebayashi H, Shimamura K, Itohara S, Parras CM, Ikenaka K. (2014) Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2. Development. 141(10):2075-84


TED Talk by Larry

  • Yu Hirota, Aki Arai, Larry J. Young, Yoji Osako, Kazunari Yuri, Shinichi Mitsui. Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles. Hormones and Behavior.  2020 120:104685.

  • Saori Yokoi, Kiyoshi Naruse, Yasuhiro Kamei, Yoshihito Taniguchi, Satoshi Ansai, Masato Kinoshita, Takeo Kubo, Teruhiro Okuyama, Shinichi Nakagawa, Larry J. Young, Hideaki Takeuchi.  Involvement of the oxytocin system for adaptive mate choice in both sexes. Proc. Natl. Acad. Sci.  2020. 117 (9) 4802-4808.

  • Kengo Horie, Kiyoshi Inoue, Shingo Suzuki, Saki Adachi, Saori Yada, Takashi Hirayama, Shizu Hidema, Larry J. Young*, Katsuhiko Nishimori*. (*equal contribution as senior author). (2019). Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors. Hormones and Behavior. 111:60-69.


  • Zhixiong He, Larry Young, Qianqian Guo, Limin Wang, Yang Yang, Luo Luo, Wei Yuan, Laifu Li, Jing Zhang, Wenjuan Hou, Fadao Tai. (2019)  Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway. eLife. 2019;8:e44026

  • Yoji Osako, Reiko Nobuhara, Young-Chang P. Arai, Kenjiro Tanaka, Larry J. Young, Makoto Nishihara, Shinichi Mitsui, Kazunari Yuri. (2018) Partner loss in monogamous rodents: Modulation of pain and emotional behavior in male prairie voles. Psychosomatic Medicine, 80:62-68.


  • Hasse Walum and Larry J. Young (2018). The Neural Mechanisms and Circuity of the Pair Bond. Nature Reviews Neuroscience. 19(11):643-654.​​​

  • Elizabeth A. Amadei, Zachary V. Johnson, Yong Jun Kwon, Aaron C. Shpiner, Varun Saravanan, Wittney D. Mays, Steven J. Ryan, Hasse Walum, Donald G. Rainnie, Larry J. Young & Robert C. Liu. (2017) Dynamic corticostriatal activity biases social bond formation in female prairie voles. Nature, 546(7657):297-301.

  • James P. Burkett, Elissar Andari, Zachary V. Johnson, Daniel C. Curry, Frans B. M. de Waal and Larry J. Young. (2016) Oxytocin-dependent consolation behavior in rodents. Science. 351:375-378.

  • Larry J. Young and Catherine E. Barrett (2015) Can oxytocin treat autism.  Science, 347:825-826 PMC4362686

  • James K. Rilling and Larry J. Young. (2014)  The Biology of Mammalian Parenting and its Impact on Offspring Social Development.  Science.  345: 771-776 PMC4306567  


        Google Scholar Citations

        View publications on PubMed

bottom of page